Will deleting all Leads, editing offline, and re-uploading Leads, disturb data in other modules?

Will deleting all Leads, editing offline, and re-uploading Leads, disturb data in other modules?

My goal is to mass edit the Leads module, removing duplicates, cleaning up fields, changing tags etc. I know that I can't make those changes without downloading leads, deleting leads from zoho module, editing offline and re-uploading. 

Will this disturb the data in other modules, if so how else can I make major changes to our leads database? The mass edit features within Zoho won't suffice

Thanks,
Casey