Can't send mails - ResponseCode 421, , Host not reachable.]

Can't send mails - ResponseCode 421, , Host not reachable.]

I can not send to some recipients:
This message was created automatically by mail delivery system.

THIS IS A WARNING MESSAGE ONLY.

YOU DO NOT NEED TO RESEND YOUR MESSAGE.

The original message was received at Thu, 31 Mar 2016 11:07:33 -0700  from xxxx@coreingenieria.cl [xxxx@coreingenieria.cl]

    ----- The following addresses had fatal errors -----   

   [Status: Error, Address: <xxxx@santanderimport.cl>, ResponseCode 421, , Host not reachable.]

 Message will be retried for 4 more day(s)

     ----- Transcript of session follows -----   

  Received:from mail.zoho.com by mx.zohomail.com

                with SMTP id 1459444928940248.1769798793456; Thu, 31 Mar 2016 10:22:08 -0700 (PDT)  Message-ID:<153cdb25179.aede58e2171520.5936546976588611551@coreingenieria.cl>

 Date:Thu, 31 Mar 2016 14:22:08 -0300

 From:Info CoreIngenieria <xxxx@coreingenieria.cl>  User-Agent:Zoho Mail  To:<xxxx@santanderimport.cl>  Subject:Test  Content-Type:multipart/alternative;

                boundary="----=_Part_394117_582448016.1459444928890"