If we mail the customer and have to wait for his response, we set the status to 'Wait Customer'.

If customer as configured an auto-responder, the ticket gets thrown on the agents desk right seconds later and additionally the agent gets an email about customers response.

How can we prevent this?

Is there a way to detect auto-responders in the flow?

As I expect this to be a common issue, does your AI/ZIA intergration provide a solution for this?