Can some advise the most common way to setup Zoho CRM to handle sales for a B2B  company?

Specifically in how to handle inbound/outbound emails.

I have spent hours researching online and can't seem to find an accepted approach, or even a tutorial.

I have Zoho One, and am already using Desk for existing customer support. But I understand that using Desk for sales emails is not the best approach.

Should I:

- Integrate Zoho Mail, and answer emails from there (and sync all emails to CRM)?

- Use Zoho Mail to receive emails, but respond to emails only from within the contact record?

- Use Sales inbox?

Can someone point me in the right direction?

Thanks!