Is there a way to apply tax to a portion of an item?

I am trying to combine several items into one item for ease of invoice creation but only one of the items is taxable.

For example

course fee $150.43  15% tax

student material $38  no tax

certification $22  no tax

instructor fee $60  no tax

local fee $6  no tax

invoice total $298.99

I'd like to add 'course' item but only calculate add tax to 150.43

is this possible?

Cheers

rich