Unable to send mail using smtp

Unable to send mail using smtp

Hi,
We are not able to send emails using SMTP settings provided by Zoho help page in our wordpress website. We tried with SSL/TLS but none of them are working.

Following error message is shown - 

SMTP ERROR: Failed to connect to server: Connection refused (111)SMTP connect() failed. https://github.com/PHPMailer/PHPMailer/wiki/Troubleshooting