The most common problem seems to be a
ResponseCode 421, Host not reachable error, which suggests that ZOHO's servers are on a blacklist.
The US Government does not blacklist companies for no reason (to the contrary, it does business with some pretty shady organizations). The fact that ZOHO's servers are apparently blacklisted is a big deal, and suggests that ZOHO is allowing spammers to use the network.
The existence of so many topics on this point - and its non-resolution - shows that ZOHO doesn't care.