Access Denied - Urgent Help Please

I am getting this error when logging in on several panels and a lot of the tabs have disappeared:
Access denied. If you are the administrator, please update your profile settings. Otherwise contact your administrator to enable the access.

I am an administrator and have checked all the profiles and permissions and all look ok. Nothing has changed I just logged in and now cant do anything.

Sent an email to support but no response yet

Any ideas?