Any drawbacks from removing ID from Ticket Subject in emails?

Any drawbacks from removing ID from Ticket Subject in emails?

Zoho's automatically adding [## XXXX ###] of course, but apparently it's possible to disable this function altogether by writing to support.

But, are there any drawbacks to that? It's certainly more pleasant to look at from customer view, and sometimes we write to automated services that require a very specific subject, so that ID overcomplicates these matters sometimes (hopefully sending an email as new ticket with unchecked adding ID to the subject works correctly).

I think Zoho also works with some sort of header information apart from the ID in subject, but is that enough? Are there considerably more falsely created new tickets instead of ticket replies or something like that?