I have tried sending emails from my website but they do not deliver. I am using an smtp plugin but still not delivering emails. I get this notification

The SMTP debugging output is shown below:

2017-07-04 03:29:09	Connection: opening to smtp.zoho.com:465, timeout=300, options=array (
                   	                  )
2017-07-04 03:29:10	Connection: Failed to connect to server. Error number 2. "Error notice: stream_socket_client(): unable to connect to smtp.zoho.com:465 (Connection refused)
2017-07-04 03:29:10	SMTP ERROR: Failed to connect to server: Connection refused (111)
2017-07-04 03:29:10	SMTP connect() failed. https://github.com/PHPMailer/PHPMailer/wiki/Troubleshooting

Please how do I fix this issue