Emails have all of a sudden started failing - Mail Delivery Status Notification (Delay)

Emails have all of a sudden started failing - Mail Delivery Status Notification (Delay)

They're not getting through at all it seems (despite it saying delay) - and to different people in completely different organisations too. Always the same response code. And only over the last few days - but it has rendered my email system entirely useless! Please help :-) 

    ----- The following addresses had fatal errors -----   

   [Status: Error, Address: <stephanie.barlow@w2wsolutions.co.uk>, ResponseCode 421, Host not reachable.]

 

Message will be retried for 4 more day(s)

 

    ----- Transcript of session follows -----   

 

 Received:from [192.168.0.23] (97e3d693.skybroadband.com [151.227.214.147]) by mx.zohomail.com

                with SMTPS id 147785960410987.82322523845698; Sun, 30 Oct 2016 13:33:24 -0700 (PDT)  Message-ID:<0552EB7E-8A6B-4E28-A1DB-69A2D641D655@candourcollaborations.co.uk>

 Date:Sun, 30 Oct 2016 20:33:19 +0000

 From:"Natasha.Newson" <natasha.newson@candourcollaborations.co.uk>

 To:Stephanie <stephanie.barlow@w2wsolutions.co.uk>

 Subject:Fwd: WHP programme Wales

 Content-Type:multipart/alternative;

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