ERROR_CODE :554, ERROR_CODE :bosimpinc14 bizsmtp Connection refused

ERROR_CODE :554, ERROR_CODE :bosimpinc14 bizsmtp Connection refused

Can Some one help me . We are having these problems with our email . All mails are returned with following msg.

This message was created automatically by mail delivery software. 
A message that you sent could not be delivered to one or more of its recipients. This is a permanent error. 

info@q-accountants.co.uk, ERROR_CODE :554, ERROR_CODE :bosimpinc14 bizsmtp Connection refused. 31.186.226.21 has a poor reputation on Cloudmark Sender Intelligence (CSI). Please visit http://csi.cloudmark.com/reset-request/?ip=31.186.226.21 to request a delisting. 



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    with SMTP id 1499350469612881.9418785610995; Thu, 6 Jul 2017 16:14:29 +0200 (CEST) 
Message-ID:<15d18408bd3.be5efb8d94122.4639610636469596874@khazina.co.uk> 
Date:Thu, 06 Jul 2017 15:14:29 +0100 
From:Mazhar Elahi <ceo@khazina.co.uk> 
User-Agent:Zoho Mail 
To:"afqoone" <afqoone@gmail.com>, "info" <info@q-accountants.co.uk> 
Subject:Letter Require 
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