How to send outgoing mail from a desktop client as one of your aliases

How to send outgoing mail from a desktop client as one of your aliases

Howdy all:

I have set up my account and am receiving and sending mail just fine through the Zoho website. I have also set up my primary me@domain.com email address in my desktop client. It receives mail from both me@domain.com and me@domain2.com (my alias). However, I can't reply from me@domain2.com. I have 2 distinct addresses and want to reply to each of them separately. I'm afraid that if I set up both accounts in my desktop client, I'll receive all the mail from my alias twice. 

Thoughts?