What causes this and what is the solution?

Network connectivity is operating normally to everything else except Zoho CRM. What I am experiencing is that I am making changes to a custom Module Layout and intermittently when I click Save it does not save. I noticed this error in the lower left corner.

If I reload the page in the browser, it loads and although it loses my changes, I can make changes and Save. After 30 to 60 seconds, the Save button does not work and I have to reload the page again.