Layout changes not taking affect

Layout changes not taking affect

I have changed the layout for my contacts & for my leads details pages and the changes are not transferring.
i've tried changing browsers, deleting cache, and restarting browsers but nothing helps.
Earlier today i also noticed my calendar was one day behind and i'm wondering if its something you guys are doing over there?

Can we get some help on this immediately please - there is another user i've noticed who is experiencing the same thing.