Mail returned "too many emails from this ISP"? These are regular contacts...

I receive the following error message when trying to email clients I contact on a regular basis. I am in their contact/address book and they are in mine. It is not just recipients with Hotmail accounts and this issue began yesterday.

ERROR_CODE :550, ERROR_CODE :SC-004 (SNT0-MC1-F30) Unfortunately, messages from 72.5.230.95 weren't sent. We recommend that you contact your Internet service provider. The problem is that too many unwanted messages have been sent from the following IP address above. You can also refer your provider to http://mail.live.com/mail/troubleshooting.aspx#errors.

Please advise.