"Error while processing the request. Unable to send message;530 5.7.57 SMTP; /client was not authenticated to send anonymous email during MAIL FROM:"

Has anyone been successful in using these products together?  I can't tell from the forums whether or not they are compatible.  Our mail being sent from the zoho.com domain get caught in SPAM folders and through the research our IT department has conducted it seems that many major services block .zoho emails.