Not able to send mail using zoho smtp

Hello,

I am using zoho smtp to send mail, but it throws.

A connection attempt failed because the connected party did not properly respond after a period of time, or established connection failed because connected host has failed to respond 165.254.168.48:587

while sending mail.

Port : 587

1) EnableSSL=true

2) EnableSSL=false

Port : 465

1) EnableSSL=true

2) EnableSSL=false

Port : 25

1) EnableSSL=true

2) EnableSSL=false