Quote Total NaN

Quote Total NaN

Does anyone else have an issue when creating quotes with the total being NaN, therefore it won't save and you have to start again!!! 

I have some quotes set up with product lines which I clone and then adjust to different customer needs. 
The problem usually happens when i try to edit the template, or move the product lines around. 

I am using multiple currencies but not within the same template. its soooooo frustrating, anyone any ideas, please help? 
Zoho say the can not replicate it.........it does not happen every time.