Remote host closed connection in response to initial connection

Remote host closed connection in response to initial connection

I have a few clients that I have with zoho and I'm now having issues on all accounts.
This is effecting 3 of my clients badly right now. Please let me know what's going on.

Event: defer warning
Sender User: // removed
Sender Domain: // removed
Sender: info@// removed
Sent Time: Jun 7, 2016 2:11:02 AM
Sender Host: localhost
Sender IP: 127.0.0.1
Authentication: localuser
Spam Score: 0
Recipient: info@// removed
Delivered To:
Delivery User: // removed
Delivery Domain: // removed
Router: lookuphost
Transport: remote_smtp
Out Time: Jun 7, 2016 3:13:03 AM
ID: 1bAD2g-0007CC-Bg
Delivery Host: mx2.zoho.com
Delivery IP: 74.201.155.220
Size: 5.62 KB
Result: Remote host closed connection in response to initial connection