ResponseCode 421, Host not reachable

Hi team,

Since Oct 30th, some of emails cannot be delivered to recipients, with ResponseCode 421, Host not reachable.
However, send to Gmail or Hotmail no problem.
Can you please help?

Here is one of them:

This message was created automatically by mail delivery system.

THIS IS A WARNING MESSAGE ONLY.

YOU DO NOT NEED TO RESEND YOUR MESSAGE.

The original message was received at Sun, 30 Oct 2016 17:49:33 -0700
from xxxx@pcdiy.com.au [ xxxx@pcdiy.com.au]

----- The following addresses had fatal errors -----
[Status: Error, Address: < xxxx@leadersystems.com.au>, ResponseCode 421, Host not reachable.]

Message will be retried for 4 more day(s)

----- Transcript of session follows -----

Received:from xxxx (58.108.199.xxx [58.108.199.xxx]) by mx.zohomail.com
with SMTPS id 1477872227041148.4332746194235; Sun, 30 Oct 2016 17:03:47 -0700 (PDT)
Message-ID:<047301d2330a$3b3a1f00$b1ae5d00$@pcdiy.com.au>
Date:Mon, 31 Oct 2016 11:03:32 +1100
From:"xxxx" < xxxx@pcdiy.com.au>
To:< xxxx@leadersystems.com.au>
Subject:remittance
Content-Type:multipart/related;
boundary="----=_NextPart_000_0474_01D23366.6EAA9700"

Thanks,
Fox