Zoho Mail Service intergration with 3rd party webmail clients

Zoho Mail Service intergration with 3rd party webmail clients

Is it possible to integrate Zoho Maile Service using 3rd party e-mail clients like RoundCube, AfterLogic, RainLoop etc.? To be honest, I don't like Zohp Mail GUI. Besides, I would like to use mail.mydomain.com to check email instead of visiting zoho.com  every single time.