Trouble shooting steps:
Testing reachability in the remote machine
You can use Telnet to test connectivity to a remote host on a specific port.
telnet assist.zoho.com 443

You can use Tracert to generate a list of intermediary routers that return ICMP "Time Exceeded" messages.
tracert assist.zoho.com

To determine where the packet transfer stopped on the network, see on which node the request has timed out.
test-netconnection assist.zoho.com -port 443

Select Run from the Start menu, and then enter inetcpl.cpl to open internet options.
Click on the "Connection" tab, and select "LAN settings"
There are 3 different ways in which proxy can be configured using internet options.
Automatically detect settings - The system automatically looks for a proxy configuration script that is responsible for delivering a list of proxies that maybe used for the request.
Use automated configuration script - This is the location where the configuration script is mentioned (PAC file).
Proxy server - The IP address and port will be specified directly using the internet options. IP address and port need to be mentioned in Address and Port field respectively.