Does a workflow stop when somebody responds to an automated email?

Does a workflow stop when somebody responds to an automated email?

We have automated email workflows that are triggered when people sign up for specific lists. Sometimes it's 1 email, sometimes 3, sometimes 5. When somebody takes a particular action on an email, we'd like the email automation to stop and our sales reps to take over. The actions would be:
  • hitting reply on the email and responding to questions we ask 
  • clicking a Calendly link and scheduling a call
Is this what automatically happens or do we need to set it in the workflow? Is it possible to integrate with Calendly or set up call scheduling through Zoho?

Thank you!