Unable to connect SMTP server:smtpout.mail.zoho.com Reason:connect timed out

Unable to connect SMTP server:smtpout.mail.zoho.com Reason:connect timed out

Trying to send email got this error 
Unable to connect SMTP server:smtpout.mail.zoho.com Reason:connect timed out

We are also not able to receive any email that were sent to us 

Please resolve.