Is it possible to search a field (text) with both "contains" and "not contains"?

Is it possible to search a field (text) with both "contains" and "not contains"?

Hello

I have a field called job title and I want to search records based on this field. For example I am trying to search for CTO. The problem is when I do a searching asking for records those job title "contains" "CTO", I also find a lot of records those job title is "director of ...".

What I would like to do is to search this field doing something like this:
- contains "cto"
- not contains "director"

Any way to do that?

Thanks