Multiple discounts in 1 invoice

Multiple discounts in 1 invoice

Hello,
Is it possible to have 2 discounts in 1 invoice? 1 at the item line level, and the other at transaction level.

For example I have 3 items: A, B, and C
A has pre-defined 10% discount from price list
B has pre-defined 5% discount from price list
C doesn't have discount

If the payment terms is 'due on receipt', additional 2% discounts will be given for all items in transaction level, or I will set the discount manually.

Is it possible? thank you in advance