Mass Delete Contacts By Import?

Mass Delete Contacts By Import?

This is a strange question but here goes:

I import a list with 400 people who we consider 'active'.
3 months from now, 100 of those will become 'inactive' and will need to be removed.

I have a way to know who those 100 are along with their emails.

Is there a way to import the 100 emails of those going 'inactive' and that somehow triggers the listing to automatically remove them?  

Basically it's a compare, tag, and delete function.

Is that even possible???

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